Clinical trials are research investigations in which people volunteer to test new treatments, interventions or tests as a means to prevent, detect, treat or manage various diseases or medical conditions.

Vigil is a fully personalized cancer immunotherapy utilizing genetically modified tumor cells. To date, we have conducted Phase 1 studies identifying the clinical dose and established the early safety profile for the platform.

The tumor types studied in Phase 1 included, but not limited to: Ovarian cancer, breast cancer, melanoma, Ewing’s sarcoma, non-small cell lung cancer, colon cancer, and hepatocellular cancer. We have also initiated Phase 2 studies in advanced ovarian cancer and Ewing’s sarcoma.

We are currently preparing to begin additional trials in advanced women’s cancers, as well as in combination with other immunotherapies, such as checkpoint inhibitors in patients with advanced women’s cancers.

Ongoing clinical trials involving Vigil®

Stage III/IV Ovarian cancer

A Randomized, Double-Blind, Placebo-Controlled Phase II Trial of Vigil Engineered Autologous Tumor Cell Immunotherapy in Subjects with Stage IIIb-IV Ovarian Cancer in Clinical Complete Response following Surgery and Primary Chemotherapy (VITAL).
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Status: Active, Not Recruiting

Advanced Gynecological Cancer

A Randomized, Intra-patient Crossover, Safety, Biomarker and Anti-Tumor Activity Assessment of the Combination of Atezolizumab and Vigil in Patients with Advanced Gynecological Cancers (A Companion Study to CL-PTL-119 VITAL).
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Status: COMPLETED

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